Nature Communications, Published online: 22 August 2026; doi:10.1038/s41467-026-77056-4 The nuclear hormone receptor NHR-49 regulates nutrition sensing and fatty acid metabolism in Caenorhabditis elegans. Here the authors show that NHR-49 activity in somatic cells regulates oocyte activation according to nutritional cues.
A somatic checkpoint through NHR-49/HNF4α governs reproductive investment and longevity in C. elegans
Siu Sylvia Lee