Regulatory factor X 7 limits Myc activity during B cell activation and suppresses Myc-dependent lymphomagenesis

Nature Immunology, Published online: 01 June 2026; doi:10.1038/s41590-026-02526-2 Guarda and colleagues investigate the role of the transcription factor RFX7 in B cell activation and lymphomagenesis. The findings indicate that Rfx7 regulates germinal center B cell, plasmablast generation and malignant transformation by restricting Myc activity.