Shengxian decoction modulates gut microbiota and microbial metabolism in rats with chronic heart failure
Qiu-hong Guo
BackgroundChronic heart failure (CHF) is a complex syndrome characterized by high morbidity and mortality, imposing a substantial global health burden. Shengxian Decoction (SXT) is a Traditional Chinese Medicine formulation that has demonstrated efficacy in treating CHF. However, its mechanism for modulating the gut microbiota in transverse aortic constriction (TAC)-induced CHF rats remains unclear.MethodsThis study identified components of SXT using liquid chromatography-mass spectrometry (LC–M