Sarcopenia promotes tumorigenesis by disrupting NOTCH-SDC2-regulated biogenesis of muscle-derived extracellular vesicles
Hong-Wen Tang
Nature Communications, Published online: 27 April 2026; doi:10.1038/s41467-026-72410-y Sarcopenia has been proposed as an independent risk factor for cancer incidence. Here, the authors demonstrate that muscle-secreted extracellular vesicles (EVs) suppress intestinal tumorigenesis in fly and mouse tumor models, and EVs from sarcopenic muscles lose anti-tumor activity due to age-related changes.