TRIM5 integrates hypoglycemic stress and influenza infection
Baojian Wu
Nature Communications, Published online: 05 May 2026; doi:10.1038/s41467-026-72791-0 Pre-existing hypoglycemia weakens the host’s interferon-based immune defense by downregulating the antiviral protein TRIM5 in the lung, thereby increasing the susceptibility to influenza infection.