Longitudinal localization of leukaemic stem cells between the metaphysis and central marrow governs their behaviour
XunLei Kang
Nature Cell Biology, Published online: 24 April 2026; doi:10.1038/s41556-026-01939-3 Wang et al. find that leukaemic stem cells preferentially localize to the metaphysis bone marrow niche and lose stemness when mobilized to the central marrow. Targeting DPP4–CXCL12–GPC3 disrupts this niche and enhances leukaemia treatment.