Nature Communications, Published online: 28 August 2026; doi:10.1038/s41467-026-76948-9 Allergic asthma involves different lung cells and mediators. Here, the authors examine the function of CD97/ADGRE5 and show that its absence increases the severity of allergic lung inflammation in mice. Allergen-pulsed Cd97-/- DCs are more activated and promote stronger type 2 immune responses than WT DCs and, in humans, lung DCs from allergen-exposed asthmatics express less CD97 than allergic non-asthmatics.