Physical, cognitive, and psychosocial fatigue are differently related to cortical complexity of superior temporal and frontal brain regions in Crohn’s disease
Jennifer Kornelsen
IntroductionFatigue is common in persons with Crohn’s disease, negatively impacting quality of life in both active and remitted disease state. Neural correlates of fatigue in Crohn’s disease are understudied, particularly relative to the separate impacts of physical, cognitive, and psychosocial fatigue. The potential moderating role of cortical complexity on the relationship between disease activity and fatigue has yet to be examined.MethodsForty-nine participants with Crohn’s disease and 49 hea