The global incidence of allergic respiratory diseases (ARDs) is rising, imposing severe socioeconomic and public health burdens worldwide. Astragali Radix (AR), a well-recognized traditional Chinese medicinal botanical drug with proven efficacy in ARDs management, exerts its therapeutic effects primarily through three major classes of bioactive metabolites: polysaccharides (e.g., APS), saponins (e.g., AS-II/IV/VII), and flavonoids (e.g., quercetin, calycosin). Of these, AS-IV and APS are the mos