Activating p53 Y220C with a mutant-specific small molecule
Nathanael S. Gray
Nature Communications, Published online: 02 May 2026; doi:10.1038/s41467-026-72165-6 The tumor suppressor protein p53 is commonly mutated in cancer and has been challenging for therapeutic reactivation. Here, the authors developed a small molecule chemical inducer of proximity to selectively activate p53 transcription and induce cellular senescence and apoptosis in p53Y220C cells.