Cardiac fibroblast deletion of PTBP1 modulates the profibrotic response by alternative splicing

Nature Communications, Published online: 11 September 2026; doi:10.1038/s41467-026-77609-7 Post-transcriptional regulation of cardiac fibroblast phenotypes during fibrotic cardiac remodeling remains poorly defined. Here, the authors demonstrate that RNA-binding protein PTBP1 regulates alternative splicing to direct the profibrotic response in multiple cardiac injury models.