Gastric dysbiosis, characterized by shifts in the microbial composition, has been increasingly associated with the development of gastric cancer, the fifth leading cause of cancer-related deaths worldwide and the second in Chile, yet its characterization through disease stages remains limited and its study in Latin American populations almost non-existent. While Helicobacter pylori is a well-established risk factor, recent evidence supports the involvement of non-Helicobacter pylori bacteria ass