BackgroundIdiopathic sudden sensorineural hearing loss (ISSNHL) is an otologic emergency with highly variable recovery despite prompt treatment. Because inflammatory chemotaxis and apoptosis are implicated in cochlear injury, serum biomarkers reflecting these pathways may improve early risk stratification.MethodsIn this single-center observational study, 209 consecutive adults with unilateral ISS…
BackgroundStereotactic radiosurgery (SRS) is widely used to treat vestibular schwannomas but may cause irreversible hearing loss due to cochlear toxicity. The underlying mechanisms are not fully understood, and no effective otoprotective therapies exist. We aimed to establish a mouse model that replicates the clinical pattern of radiation-induced hearing loss.MethodsC57BL/6J mice (n = 31) receive…
