Journal of Controlled Release

We developed an injectable and transient hydrogel with a programmable lifetime by introducing closed functional loops, specifically gelation and sol transition pathways, within the system. Gelation occurs through the formation of coordination crosslinking between a phosphate ester and its affinity ligand, while enzymatic degradation of the phosphate ester triggers the sol transition pathway. The …

Spinal cord injury (SCI), characterized by a sequential, spatiotemporally heterogeneous pathological progression encompassing primary injury, acute/subacute, intermediate and chronic phases, remains a devastating clinical challenge with limited effective therapies. Conventional hydrogel-based delivery system cannot dynamically match the spatiotemporally evolving pathological microenvironment of S…

Efficient intracellular delivery of therapeutic enzymes remains a central limitation of protein-based therapies. In lysosomal storage disorders such as Pompe disease, classical enzyme replacement therapy (ERT) is particularly constrained by inefficient delivery to skeletal muscle, limited cellular uptake, and immunogenicity. Here, we introduce a lipid nanoparticle (LNP) platform designed for char…

In clinical settings, the intensive use of antibiotics, particularly in intensive care settings, leads to a significant increase in the number of bacterial species that are resistant to treatments. In this context, biofilm is a crucial virulence factor that enable bacteria to persist within the host, often resulting in the need for extensive antibiotic treatment. Staphylococcus epidermidis, a not…

This study demonstrates the development of a viscoelastic hydrogel-based matrix designed to promote physiological tissue microenvironment in 3D cell cultures, utilizing hyaluronic acid-a natural constituent of the extracellular matrix-as the primary polymer. The use of dynamic covalent chemistry, specifically boronate ester bonds, allows for the creation of a tunable biomimetic material with reve…