Self-adaptive hydrogels for treatment of spinal cord injury

Spinal cord injury (SCI), characterized by a sequential, spatiotemporally heterogeneous pathological progression encompassing primary injury, acute/subacute, intermediate and chronic phases, remains a devastating clinical challenge with limited effective therapies. Conventional hydrogel-based delivery system cannot dynamically match the spatiotemporally evolving pathological microenvironment of SCI, whereas self-adaptive hydrogels can recognize the dynamic pathological cues within the lesion mic