Injectable and transient hydrogel with programmable lifetime by endogenous coordination crosslinking and enzymatic de-crosslinking

We developed an injectable and transient hydrogel with a programmable lifetime by introducing closed functional loops, specifically gelation and sol transition pathways, within the system. Gelation occurs through the formation of coordination crosslinking between a phosphate ester and its affinity ligand, while enzymatic degradation of the phosphate ester triggers the sol transition pathway. The transition from the gel to the sol state was driven by the dissipation of a transient thermodynamic s