Cancer Plus

Nivolumab is a standard-of-care treatment for relapsed/refractory (r/r) Hodgkin lymphoma (HL) and is approved for selected non-Hodgkin lymphoma (NHL) subtypes. However, high costs significantly restrict nivolumab accessibility, particularly in the developing world. This study aims to report treatment outcomes in patients with r/r HL and r/r NHL treated with standard or reduced doses of nivolumab …

Hepatocellular carcinoma (HCC) and major depressive disorder (MDD) are characterized by shared pathophysiological mechanisms. However, the specific molecular indicators and the fundamental biological pathways driving this connection have yet to be fully elucidated. This study aims to identify immune-related molecular signatures shared by HCC and MDD using a systems biology approach and to evaluat…

Parotid gland tumors are rare, exhibit complex histopathology, and often lack early clinical symptoms. Epidemiological and pathological features of parotid gland tumors in Anhui province, China, have not yet been reported. This study aimed to retrospectively analyze the distribution and histopathological characteristics of parotid gland tumors in Anhui province. We retrospectively analyzed the cl…

Brain metastases are common in metastatic non-small cell lung cancer (NSCLC) and portend poor outcomes, yet prognostic determinants—particularly whether brain metastases are present at diagnosis or develop during follow-up—remain incompletely characterized in driver-negative patients treated with first-line platinum-based doublet chemotherapy. This retrospective study evaluate…

Although DNA damage-inducible transcript 3 (DDIT3) has been identified as a novel gene associated with breast cancer, its clinical significance, biological function, and underlying mechanisms remain unclear. By integrating immunohistochemistry with data from The Cancer Genome Atlas (TCGA), we discovered that elevated levels of DDIT3 Messenger RNA and protein expression are significantly associate…

Natural killer group 2, member D (NKG2D) ligands are highly expressed in various tumor cells and therefore represent an attractive target for cancer immunotherapy. A bispecific T-cell engager (BiTE) with a fused extracellular domain of NKG2D and an anti-CD3 single-chain fragment variable (scFv) has shown significant anti-tumor potency. To circumvent the manufacturing challenges and short serum ha…

Cancer stem cells (CSCs) pose a significant challenge in tumor treatment due to their ability to remain quiescent during therapy and thus evade chemo- and radio-therapy. In addition, their ability to initiate tumor formation from a single cell is another essential factor to consider when developing a strategy to eradicate CSCs. Given that developing novel drugs is a time-consuming and costly proc…

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. Although the coiled-coil domain-containing protein 51 (CCDC51) has been implicated in retinal pathologies, its function in HCC remains poorly defined. Here, we report that reduced CCDC51 expression is associated with favorable clinical outcomes in HCC patients. Bioinformatic analyses revealed significant corr…

Conventional computed tomography-magnetic resonance imaging (CT-MRI) fusion for head and neck radiotherapy is often limited by registration uncertainty from inconsistent positioning and immobilization between diagnostic MRI and CT simulation. This study evaluates the practicality of using MRI positioning plates for head and neck tumors through image registration. A total of 35 patients with head …

Multiple myeloma (MM) is a hematological malignancy characterized by the proliferation of plasma cells in the bone marrow, leading to organ dysfunction. Globally, the incidence of MM has increased substantially in recent decades, necessitating an updated understanding of its global burden and epidemiological trends. This study utilized data from the Global Burden of Disease database to analyze th…

Colorectal cancer (CRC) has been associated with metabolic and inflammatory dysregulation, particularly in lipid and glucose metabolism. This study investigates the role of serum lipids and biochemical markers as potential biomarkers for CRC in the South Indian population. A case–control observational study was conducted involving 65 CRC patients and 65 age- and sex-matched healthy cont…

Despite advancements in diagnostic and therapeutic strategies, early detection and improved prognosis of gliomas remain challenging. A deeper understanding of glioma pathogenesis and the identification of reliable biomarkers are crucial for early diagnosis and the reduction of healthcare costs. Mitochondrial ribosomal protein S33 (MRPS33), a key component of mitochondrial protein synthesis, has n…

This case report highlights the diagnostic challenges and therapeutic considerations when dermatofibrosarcoma protuberans (DFSP) present in atypical locations, such as the head and neck. A 46-year-old Hispanic male presented with a large, rapidly growing, protruding mass on the left medial forehead, initially diagnosed through ultrasound as a benign cyst. The lesion exhibited a significant increa…

Geraniin, an ellagitannin present in many seeds, nuts, fruits, and plants, has anticancer, antioxidant, antiviral, antimicrobial, antimutagenic, cardiovascular protective, and hypoglycemic properties. Geraniin was tested for its anticancer and plasma protein-modifying properties in a syngeneic mouse model of breast cancer (BC). A mouse mammary cancer cell line (4T1) was injected into the mammary …

Head-and-neck squamous cell carcinoma (HNSCC) is a complex malignancy characterized by a highly heterogeneous tumor microenvironment (TME) that influences tumor progression, metastasis, and therapeutic resistance. Despite significant advancements in understanding HNSCC at the molecular level, comprehensive analyses of TME-related research within this domain remain limited. Hence, this study prese…

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, with metastasis significantly impacting patient outcomes. Alpha lipoic acid (ALA), a potent antioxidant, has shown promise in cancer treatment due to its ability to modulate key cellular pathways. The AMP-activated protein kinase (AMPK)-p53 axis plays a critical role in regulating cellular metabolism and tumo…

The widespread use of plastic has led to growing concerns about the release and impact of microplastics and nanoplastics (MPNPs) on both the environment and human health. The surge in plastic production during the COVID-19 pandemic increased the potential for human exposure through ingestion, inhalation, and dermal absorption. MPNPs pose significant health risks due to their mutagenic and carcino…