The impact of brain metastasis and other factors on overall survival in patients with metastatic non-small cell lung cancer

Brain metastases are common in metastatic non-small cell lung cancer (NSCLC) and portend poor outcomes, yet prognostic determinants—particularly whether brain metastases are present at diagnosis or develop during follow-up—remain incompletely characterized in driver-negative patients treated with first-line platinum-based doublet chemotherapy. This retrospective study evaluated prognostic factors affecting overall survival (OS) in patients with metastatic NSCLC who had brain