Evaluating anticancer effects of geraniin supplementation in a syngeneic mouse model of breast cancer: Identification of differentially regulated plasma proteins
Huang Hui·Ammu Kutty Radhakrishnan·Jeya Seela Anandha Rao·Nurul H. Rutt·Sunil Pazhayanur Venkateswaran·Nurul Shielawati Mohamed Rosli·Caihong Xin·Nur Diana Anuar
Geraniin, an ellagitannin present in many seeds, nuts, fruits, and plants, has anticancer, antioxidant, antiviral, antimicrobial, antimutagenic, cardiovascular protective, and hypoglycemic properties. Geraniin was tested for its anticancer and plasma protein-modifying properties in a syngeneic mouse model of breast cancer (BC). A mouse mammary cancer cell line (4T1) was injected into the mammary pad of female BALB/c mice to produce BC. Daily oral gavage of geraniin (0.5 mg) or soy oil was given