Alpha lipoic acid as a modulator of the AMPK-p53 axis: Mechanisms and therapeutic potential in hepatocellular carcinoma progression

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, with metastasis significantly impacting patient outcomes. Alpha lipoic acid (ALA), a potent antioxidant, has shown promise in cancer treatment due to its ability to modulate key cellular pathways. The AMP-activated protein kinase (AMPK)-p53 axis plays a critical role in regulating cellular metabolism and tumor suppression, making it an attractive target for HCC therapy. This review aims to elucidate the pote