Are you still recruiting for “hypertension”… or for the full cardiometabolic reality your protocol actually requires? Hypertension used to be treated (and recruited) as a single-variable disease: elevated blood pressure. That model no longer reflects clinical reality. Today’s hypertension patient is increasingly part of a broader cardiometabolic profile: obesity, insulin resistance, type 2 diabetes, and cardiovascular risk factors are deeply interconnected. Emerging research continues to show that therapies targeting weight and metabolic pathways (including GLP-1–based treatments) also drive meaningful reductions in blood pressure. For sponsors, this changes more than treatment strategy. It changes recruitment strategy. Because the patient you need is no longer “someone with high blood pressure.” It’s someone with the right combination of conditions, history, and treatment status.