Decoding stereospecific metabolic regulation of protein modifications
Zhijun Zhu
Nature Chemistry, Published online: 20 May 2026; doi:10.1038/s41557-026-02157-y Metabolites can regulate protein structure and function via covalent modifications, with different isomers exerting distinct effects. Now, stereospecific O-2-hydroxyglutarylation by oncometabolites D2HG and L2HG has been uncovered on distinct proteomes, revealing a chiral layer of post-translational regulation that tunes kinase signalling.