Nature Communications, Published online: 20 August 2026; doi:10.1038/s41467-026-76850-4 Accurate gas sensing remains challenging because conventional semiconductor sensors often struggle with selectivity and interference from complex gas mixtures. Here, the authors use a single-atom catalyst strategy to stabilize isolated Pt atoms on regionalized SnO₂ surfaces, enabling selective and antiinterference NO₂ detection. The resulting sensor operates continuously in air for more than 550 days and achieves high classification accuracy across a library of 37 gases, highlighting the promise of single-atom-engineered sensors for reliable gas monitoring.