IntroductionDental caries, a highly prevalent oral disease, significantly compromises oral health. Dental biofilms represent a key etiological factor in caries pathogenesis and pose challenges for eradication due to their protective extracellular matrix.MethodsHerein, we rationally designed a ferro-polydopamine nanozyme (FPN) featuring a flower-like morphology and remarkable peroxidase-like (POD-like) activity.ResultsSignificantly, FPN efficiently catalyzed low-concentration H2O2 under mildly ac