Shikonin and Co2+ self-assembled nanoparticles promote diabetic wound healing via antioxidant effects

This study successfully constructed shikonin-Co nanoparticles (Co-Shik NPs) and systematically evaluated their healing effects on diabetic wounds. The nanoparticles, prepared via a self-assembly method, exhibited uniform particle size and stable structure. In vitro experiments demonstrated that the material showed no cytotoxicity at a concentration of 16 mg/L, significantly scavenged reactive oxygen species, and reduced the H2O2-induced apoptosis rate from 25.1% to 10.31%. Animal experiments rev