Altered expression of MX2 and SAMD4A in PBMCs predicts early treatment responses in HBeAg-positive chronic hepatitis B patients during Peg-IFN-α therapy

BackgroundChronic Hepatitis B (CHB) is a major global health concern. This study aimed to evaluate whether myxovirus resistance 2 (MX2) and sterile alpha motif domain containing 4A (SAMD4A) mRNA levels in peripheral blood mononuclear cells (PBMCs) can predict early treatment responses to pegylated interferon-alpha (Peg-IFN-α) in hepatitis B e antigen (HBeAg)-positive CHB patients.MethodsThis prospective cohort study enrolled HBeAg-positive CHB patients who received Peg-IFN-α for 48 weeks. Patien