Study on the analgesic and anti-inflammatory mechanisms of Jingu Zhitong gel in the treatment of knee osteoarthritis through the IL-17, NGF-TrkA, and COX-2/PGE2 pathways
Wei Xiao
IntroductionKnee osteoarthritis (KOA) is a degenerative bone and joint disease. Jingu Zhitong Gel (JGZTG) exhibits a promising therapeutic effect in the clinical treatment of knee osteoarthritis (KOA). However, the mechanism of JGZTG in treating KOA remains unclear.MethodsWe established a rat model of KOA through surgery and treated rats with JGZTG for 21 days. The pain threshold was measured by the Ugo Basile joint pain tester, the weight bearing on the right foot was detected by a bipedal bala