The World Health Organization (WHO) has designated carbapenemase-producing Klebsiella pneumoniae (CP-KP) as a critical priority pathogen due to its increasing importance for human health. Although wastewater-based surveillance (WBS) is discussed as a complementary tool for classical systems regarding hazard forecasting and early-warning, methods targeting a single AMR target remain scarce. Therefore, we applied an integrated “wet-lab to genomics” workflow to support reliable target detection of