m 6 A modification suppresses innate anti-tumour immunity in colorectal cancer by limiting alu-derived dsRNA accumulation
Parinaz Mehdipour
Nature Communications, Published online: 14 May 2026; doi:10.1038/s41467-026-73211-z Retroelement transcripts-derived double-stranded RNAs (dsRNAs) can trigger innate immune responses in cancer through a process known as viral mimicry. Here the authors show that METTL3, the writer of m6A modification, regulates the abundance of steady-state dsRNAs and it could be targeted together with DNA methyltransferases to enhance viral mimicry in colorectal cancer therapy.