The primary difference between Retatrutide and Zepbound lies in their hormonal targets and how they manipulate metabolism. Zepbound (tirzepatide) is a dual agonist that mimics two hormones: GLP-1 and GIP, primarily driving weight loss by suppressing appetite and slowing digestion. Retatrutide is a next-generation triple agonist that adds a third hormone: glucagon. While Zepbound helps the body store less fat by managing insulin, Retatrutide actively forces the body to burn existing fat. The adde