(-)-Englerin A binding to human TRPC5 exposes an aromatic interaction network in channel activation
Robin S. Bon
Nature Communications, Published online: 29 April 2026; doi:10.1038/s41467-026-71840-y The plant natural product (-)-englerin A (EA) is a potent, selective agonist of TRPC1/4/5 channels. Here, key structural determinants of EA-mediated channel activation are revealed through single-particle cryo-electron microscopy and mutagenesis studies.