Self-assembling scaffolds epigenetically reactivate and electroactively guide neuronal regeneration to restore central neural circuits
Jun Chen
Nature Communications, Published online: 04 May 2026; doi:10.1038/s41467-026-72397-6 CNS injury disrupts neural circuits, with poor regeneration due to HDAC retention and hostile environments. Here, the authors show a nanosystem with LMK-235 that forms electroactive scaffolds and promotes regeneration and enhances synaptic reconnection