Ethnopharmacological RelevanceBunium persicum is a valued traditional Persian medicinal spice used as a calming and anxiolytic agent. However, the bioactive metabolites responsible for its antioxidant and anxiolytic effects, and their underlying mechanisms, remain largely unexplored.Aim of the StudyThis study evaluated the antioxidant and anxiolytic potential of hydroalcoholic extracts and solvent fractions of B. persicum fruits through bioactivity-guided isolation, supported by in-vivo and in s