Phosphoethanolamine: a translational journey from biological process and physiopathological effects to therapeutical innovation - a mini-review
Durvanei Augusto Maria
Phosphoethanolamine (pETN), an endogenous metabolite in the Kennedy pathway for membrane phospholipid synthesis, can be chemically synthesized and exemplifies translational pharmacology through its journey from basic biochemistry to clinical application. Initially recognized for phosphatidylethanolamine biosynthesis via PCYT2-mediated conversion, pETN gained clinical attention following reports of Brazilian cancer patients with pETN-containing products. Subsequent pharmacological studies reveale