Diet-induced obesity impairs refeeding responses and downregulates lateral septal GLP-1R in male rats: an effect reversed by weight-loss treatment
Ramón Sotomayor-Zárate
IntroductionThe lateral septum (LS) is a brain area involved in important physiological functions such as reward, stress response, and autonomic regulation. The LS is one of the brain areas with the highest expression of the glucagon-like peptide-1 receptor (GLP-1R), and pharmacological modulation of GLP-1R in the LS affects food intake. However, the relationship between obesity development and LS dysregulation of the GLP-1/GLP-1R system has been poorly studied.MethodsWe aimed to investigate whe