Aptamer-ASO Chimera: Precision Delivery of Therapeutic Oligonucleotides for Targeted Gene Silencing

Technology Overview Aptamer-ASO chimeras are innovative bifunctional oligonucleotide therapeutics that combine the high-affinity targeting of aptamers with the gene-silencing capabilities of antisense oligonucleotides (ASOs) [1]. This hybrid design enables precise delivery of ASOs to specific cells or tissues, enhancing therapeutic efficacy while minimizing off-target effects. By leveraging aptamers’ ability to bind cell-surface biomarkers (e.g., receptors, proteins), the chimera selectively...