CHARACTERIZATION OF HYPEROXIA-INDUCED LUNG INJURY IN ADULT FEMALE RATS
Abraham G. Taye
Acute Respiratory Distress Syndrome (ARDS) is a life-threatening lung disease that results from direct or indirect insults to the lung, leading to air-blood barrier damage, pulmonary edema, hypoxemia, and multi-organ failure. Hyperoxia, or exposure to high fractions of oxygen, is used as a life-saving therapy to improve blood oxygenation in patients with ARDS. However, it can also worsen lung injury by inducing excessive production of reactive oxygen species (ROS), primarily from mitochondria, a