Nature Communications, Published online: 23 June 2026; doi:10.1038/s41467-026-74661-1 Primary amines are one of the most versatile intermediates in synthetic chemistry but current methods for their production rely on the use of protecting groups in multistep reactions or the use of corrosive reducing agents. Herein, the authors report a synthetic method for primary amines that is based on accelerated microdroplet chemistry.