STAT3 signaling is associated with neuroimmune dysregulation in a Dravet syndrome model and pediatric drug-resistant epilepsy

BackgroundDravet syndrome (DS) is a severe developmental and epileptic encephalopathy, mainly caused by SCN1A gene mutations. Its core characteristics are heat sensitivity and refractoriness, and immunoinflammatory factors can participate in the occurrence and development of the disease. At present, the regulatory role of immune inflammation activation in DS has been confirmed, but the specific molecular core connecting systemic inflammation and central nervous system signals and its translation