Nature Catalysis, Published online: 25 June 2026; doi:10.1038/s41929-026-01558-z Continuous-flow photocatalysis is frequently hindered by the need to reconcile light absorption, mass transfer, and catalyst recovery, reflecting a fundamental trade-off between molecular efficiency and operational practicality. Now, a study shows that stable covalent organic framework (COF) nanofluids combine structural definition with dynamic mobility. This design enables rapid and scalable achiral and chiral oxid