Background. Soyeom-Jetong (SJ) is a traditional East Asian polyherbal formulation composed of Paeonia lactiflora Pallas, Glycyrrhiza inflata Batal, and Corydalis yanhusuo W.T. Wang, traditionally used for treating inflammatory disorders. Given the central role of the NLRP3 inflammasome in inflammation-related pathologies, SJ is of particular interest as a potential anti-inflammatory modulator. However, the molecular mechanisms underlying the anti-inflammatory effects remain unclear. This study a