Isoviolanthin suppresses IL-1β-induced inflammatory and catabolic responses in chondrocytes
Xu-Bo Wu
BackgroundKnee osteoarthritis (KOA) is characterized by the progressive degeneration of articular cartilage, necessitating novel therapeutic strategies to halt disease progression. Isoviolanthin, a natural flavonoid glycoside, has an unclear mechanism of action in KOA.MethodsWe employed network pharmacology and molecular docking, supported by in vitro assays, to investigate the mechanisms of isoviolanthin in KOA. Predicted targets of isoviolanthin were intersected with KOA-related genes from pub