Shared molecular mechanisms in aging and neurodegenerative diseases: from mechanistic insights to therapeutic strategies
Kevser Kübra Kırboğa
Aging is a complex biological process characterized by progressive functional decline and increased vulnerability to age-related diseases, particularly neurodegenerative disorders. At the biological level, aging is characterized by a range of molecular and cellular mechanisms, including genomic instability, telomere attrition, loss of proteostasis, mitochondrial dysfunction, and chronic inflammation, which collectively contribute to cognitive decline and neuronal dysfunction over time. These hal