Nature Cell Biology, Published online: 02 June 2026; doi:10.1038/s41556-026-01961-5 Hoslett et al. show that trapped PARP1 is cleared from the nucleus by nucleophagy involving the autophagy receptor TEX264 and p97. Inactivation of nucleophagy resensitizes acquired resistance of BRCA1-deficient cells to PARP inhibitors.