Drug Design Strategies Targeting PCSK9: From Antibodies to Small Molecules

Hyperlipidemia is one of the most significant controllable risk factors for cardiovascular and cerebrovascular diseases such as myocardial infarction and stroke. These conditions have long ranked among the leading causes of death worldwide, posing a serious threat to public health. Dyslipidemia is not only directly linked to atherosclerosis but is also closely associated with metabolic disorders such as nonalcoholic fatty liver disease, type 2 diabetes, and chronic kidney disease. Although...