Outer membrane vesicles from Akkermansia muciniphila antagonize chronic stress-induced colorectal cancer progression by downregulating Fetuin-A
Yuhong Li
IntroductionChronic stress is known to exacerbate the malignant progression of colorectal cancer (CRC), a leading cause of cancer-related mortality worldwide. While outer membrane vesicles (OMVs) derived from Akkermansia muciniphila (A. muciniphila) exhibit anti-tumor potential, their underlying mechanisms in the context of stress remain unclear. This study investigated whether A. muciniphila OMVs could mitigate chronic stress-induced CRC progression by regulating the pro-tumorigenic protein Fet