Nature Communications, Published online: 21 August 2026; doi:10.1038/s41467-026-76702-1 This study identifies four antigenic sites on CCHFV NP, showing that protection is independent of head or stalk location. It maps the highly conserved binding epitope of mAb-9D5 in the head domain, enabling broad-spectrum efficacy and opening the door for effective combination therapies.
Structural and mechanistic insights into protective non-neutralizing antibodies targeting Crimean-Congo hemorrhagic fever virus nucleocapsid protein
Scott D. Pegan