IntroductionDepression remains a leading global health issue, with many patients failing to respond to traditional treatments. Emerging research links depression to gut microbiota dysbiosis, suggesting a role for microbiota-based interventions. This study explores the effects of Mongolian Andai therapy on gut microbiota and metabolites in depressed patients.MethodsTwenty patients with depression underwent 8 weeks of Andai therapy. Gut microbiota was analyzed using 16S rRNA sequencing, and blood