The Alzheimer’s Blueprint: Dr Alison Goate and Her Team’s Genetic Breakthrough

For decades, Alzheimer’s disease was largely viewed as an inevitable consequence of ageing. But in 1991, Dr Alison Goate and her team uncovered a genetic mutation linked to familial Alzheimer’s disease, a breakthrough that transformed modern neuroscience. In this piece, Élise Goate explores the discovery that reshaped Alzheimer’s research, the legacy of the Amyloid Hypothesis, and the ongoing impact of women in genetics and neuroscience today.