ObjectiveImmediate postictal potentiation (PIP), a unique phenomenon observed in immature animals, may contribute to the enhanced sensitivity of young animals to seizures and epilepsy. PIP deserves more experimental attention because understanding its mechanisms could provide valuable insights into treating these conditions.MethodsUsing the technique of cortical afterdischarges (ADs), we analyzed the effect of glutamate receptor antagonists on PIP in 12-day-old rats. A conditioning AD was record